GOUT BLOG

Gout Blog!Gout is one of the oldest and most painful forms of Arthritis known to man.

Related to Kidney disease, and also Heart Failure, Sleep Apnea, obesity, kidney stones, spinal problems,and joint maiming


Gout is caused by excess uric acid in the body that the kidneys were unable to flush out or could be dissolved in the blood stream.

The Uric acid then forms into barbed Crystals which head for the bodies extremities and tear into the synovial sacks in the joints, causing extreme pain and swelling.

Long term effects are Kidney failure or Kidney stones, Heart failure and debilitating maiming of the joints of the body.Gout and its side effects can completely make any size person unable to move from their bed, it is a disease that is not to be taken lightly. Gout can be maintained by powerful medicines that can be harmful to use if one is not careful,especially over a long term usage and it can also be maintained by Herbal remedies.

This is one mean painful beast.

In Gout Blog I will be adding various bits of Information into this area in the weeks to come. If you like you can easily get an RSS feed of this site and Gout Blog, and get updates as I write them.

There are questionnaires within the Gout-aware website and Gout Blog that are quick and can be beneficial for you to fill them in, as it is interesting to see what areas other people suffer their pain in and what medicines they use.

One Questionnaire is in the medicine section the other is a standalone questionnaire.

Any Comments and articles you would like to submit feel free. All email can be sent to

[email protected]

regards

Peter

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The Gout Aware Story

The Gout aware story of how a Gout symptom sufferer started Gout Aware the website for Gout sufferers

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Arnica Gout

Arnica Gout is not a real Gout term as Arnica is only a healing tool to help alleviate gouty symptoms.

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Treating Gout Symptoms using Cherries

There are many gout remedies available, one is Treating Gout Symptoms using Cherries

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Flax Seed Oil and Gout

There are many Gout remedies and one is Flax seed oil and Gout which is an unusual marriage in maintainence.

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Canine Gout

Though Rare dogs can get Canine Gout which is a form of Gout that similar to Human Gout.

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New York Times Latest Gout information

Latest information on Gout from the New York Times.

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Gout Facts

Gout Facts

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Medical Feeds


Gout Blog:
Latest Gout feed information

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Gout and Alcohol

There are extremely strong links between Gout and Alcohol which have been researches extensively.

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"“People wish their enemies dead, but I do not; I say give them the gout, give them the stone!”! 'Mary Worley Montagu '


Gout Blog:

A study led by a team of scientists in Scotland suggests that genes may play a part in increasing one's risk of developing gout, a painful condition that affects the joints.

The study is published in the 9 March online issue of Nature Genetics and is the work of researchers based at the MRC Human Genetics Unit, Western General Hospital, Edinburgh, and colleagues from other research centres in the UK and also in Croatia and Germany.

Gout (also called metabolic arthritis) is a painful condition caused when uric acid, a waste product of purine metabolism that in humans and great apes is mostly excreted via the kidneys into urine, deposits in the joints.

In some people the kidneys don't clear all the uric acid from the bloodstream, a condition that is called hyperuricemia.

Some 10 per cent of people with hyperuricemia go on to develop gout, where uric acid is deposited in the joints as monosodium urate crystals, resulting in inflammation and often considerable pain. The condition usually affects the joint of the big toe, but it can also affect fingers, elbows, ankles, knees and other joints.

Causes of gout have often been attributed to diet and lifestyle, with overconsumption of protein, refined sugar and alcohol being the main culprits, but the mystery that has remained is why thousands of people with these lifestyles don't develop gout.

The answer, according to this study, could be genetic. The researchers studied the genes of more than 12,000 people and found that a gene variant may increase or lower the risk of a person developing gout.

The gene variant in question is called SLC2A9, already known to scientists as a transporter of fructose, but in this new study, the researchers, led by Professor Alan Wright of the MRC Human Genetics Unit, found the variant also plays a key role in transporting uric acid.

Wright and colleagues found that between 1.7 and 5.3 per cent of the variance in blood levels of uric acid was explained by the presence of this gene variant in a Croatian population sample, and that SLC2A9 was also linked with low levels of uric acid excretion and/or gout in population samples from the UK, Croatia and Germany.

The presence of the gene variant appears to impede the ability of the kidneys to filter uric acid from the bloodstream.

According to a BBC News report, Wright said that:

"The gene is a key player in determining the efficiency of uric acid transport across the membranes of the kidney."

The level of risk that a person has for gout will depend on which form of the gene they have inherited, said the researchers, who hope this discovery will lead to the development of improved diagnostics for the condition.

The traditional view of gout is often associated with historical stereotypes of overindulgent people who eat and drink to excess, but in reality this often not the case, with estimates placing about 1 million people in the UK suffering from some form of gout.

A representative of the British Society for Rheumatology, Professor Stuart Ralston told the BBC that he often saw people with gout who did not fit the stereotype of excessive drinking and eating of rich food, saying he knew of many patients that were "quite abstemious". Perhaps this study reveals a genetic marker for gout risk, he said, and that it could be a "target for new gout drugs". There are few medications that treat gout.

Another expert told BBC News there appears to be a link between this study and another one that suggested excessive drinking of sugary soft drinks also increased the risk of gout, since the gene variant that appears to control the ability of the body to remove uric acid from the blood is the same one that transports fructose, a sugar often found in soft drinks.

"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.Veronique Vitart, Igor Rudan, Caroline Hayward, Nicola K Gray, James Floyd, Colin NA Palmer, Sara A Knott, Ivana Kolcic, Ozren Polasek, Juergen Graessler, James F Wilson, Anthony Marinaki, Philip L Riches, Xinhua Shu, Branka Janicijevic, Nina Smolej-Narancic, Barbara Gorgoni, Joanne Morgan, Susan Campbell, Zrinka Biloglav, Lovorka Barac-Lauc, Marijana Pericic, Irena Martinovic Klaric, Lina Zgaga, Tatjana Skaric-Juric, Sarah H Wild, William A Richardson, Peter Hohenstein, Charley H Kimber, Albert Tenesa, Louise A Donnelly, Lynette D Fairbanks, Martin Aringer, Paul M McKeigue, Stuart H Ralston, Andrew D Morris, Pavao Rudan, Nicholas D Hastie, Harry Campbell and Alan F Wright.Nature Genetics Published online: 09 March 2008DOI:10.1038/ng.106.

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Written by: Catharine Paddock, PhDCopyright:  MedicalNews Today RSS FEED

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Sources: Journal abstract, BBC News.

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Treatment For Gout And The Condition's Protective Effects

Gout Blog:

The goal in treating patients with gout is to reduce acute attacks by lowering serum urate levels, which are usually high in this disease. At the same time, high serum urate levels have been shown to lower the risk of developing Parkinson's disease (PD). A new study compared the safety and efficacy of febuxostat, a new drug being developed for gout that was recently approved for use in Europe, and a commonly used drug that has been around for years. Another study examined the link between gout and PD in individuals 65 years and older. The studies were published in the November issue of Arthritis Care & Research (http://www3.interscience.wiley.com/journal/77005015/home).

For many years, the most common drug used to treat gout was allopurinol, which is generally safe and effective, but has been known to cause life-threatening rashes in rare cases. Its dosage often has to be reduced in patients with impaired kidney function, but previous clinical trials have shown that febuxostat is effective at lowering urate levels and that its dosage may not need to be adjusted.

A Phase III, randomized, double-blind multi-center trial, known as the APEX (Allopurinol- and Placebo-Controlled, Efficacy Study of Febuxostat) trial, was conducted to compare the safety and efficacy of febuxostat with allopurinal and a placebo in patients with high urate levels (uricemia) and gout, some of whom had impaired renal function. It was the largest randomized controlled clinical trial to date comparing the two drugs. Led by H. Ralph Schumacher of the University of Pennsylvania, the 28-week trial involved 1,072 patients at 167 sites in the U.S. who had serum urate levels of at least 8 mg/dl and gout, with normal or impaired renal function. Patients were randomized to receive one of three dosage levels of febuxostat once daily; allopurinol; or a placebo. The allopurinol dose given was based on kidney function; those with normal function received half the normal dose.

The results showed that a significantly greater proportion of patients receiving febuxostat at any dose achieved serum urate levels below 6 mg/dl for the last three months in which they participated in the trial. In those with impaired kidney function, about half in the febuxostat groups reached this level, while none of the patients with renal impairment who received the lower dose of allopurinol reached it. During the first eight weeks, more patients receiving febuxostat needed treatment for flares compared with the other groups. This may have been due to a more abrupt lowering of urate levels that caused crystal mobilization. Adverse events, mostly mild to moderate, occurred with similar frequency across the treatment groups.

The authors conclude that febuxostat's effects at these dosage levels "are significantly greater than those produced by the commonly used doses of up to 300 mg of allupurinol or by placebo," adding that "The efficacy of febuxostat in subjects with renal impairment is promising and warrants further study."

In another study published in the same issue, researchers led by Hyon Choi of the Arthritis Research Centre of Canada in Vancouver, identified 11,258 patients aged 65 or older with gout and 56,199 age and sex matched controls. They divided the gout patients according to those who were being treated with at least one prescription (72 percent) and those who did not receive any prescriptions for anti-gout medication during the study period, which was 1991 to 2004. They also included data on other medical conditions and medication use, such as diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs) known to be associated with gout or PD risk.

During the follow-up period, which averaged about eight years, they identified 1,182 new cases of PD. They found a 30 percent reduction in the risk of PD among those with a history of gout, independent of age, sex, prior medical conditions and use of diuretics and NSAIDs.

"These findings lend further support to the purported protective role of uric acid against PD," the authors state, adding a potential caution that lowering urate levels too much too long might also have harmful neurodegenerative consequences such as PD.

Gout Blog----------------------------Article adapted by Medical News Today from original press release.

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