Gout and Hyperuricemia

Gout and Hyperuricemia - The four phases of gout include asymptomatic hyperuricemia.
Hyperuricemia is an abnormally high level of uric acid in the blood.


Gout and Hyperuricemia are both undissociated uric acid and the monosodium salt (primary form in blood) are only sparingly soluble.

The limited solubility is not ordinarily a problem in urine unless the urine is very acid or has high [Ca2+].

[Urate salts coprecipitate with calcium salts and can form stones in kidney or bladder.] A very high concentration of urate in the blood leads to a fairly common group of diseases referred to as gout.

This can also lead to kidney disease.

Gout has 4 phases or stages, the first is asymptomatic hyperuricemia, which s the most common form and generally not treated by a doctor until it moves into the next stage called acute gouty arthritis.

According to

MARK D. HARRIS, M.D., Wilford Hall, USAF Medical Center, San Antonio, Texas

LORI B. SIEGEL, M.D., Finch University of Health Sciences, Chicago Medical School, Chicago, Illinois

JEFFREY A. ALLOWAY, M.D., Wilford Hall, USAF Medical Center, San Antonio, Texas

Am Fam Physician. 1999 Feb 15;59(4):925-934. The chart below shows Hyperuricemia predisposes patients to both gout and nephrolithiasis, but therapy is generally not warranted in the asymptomatic patient. Recognizing hyperuricemia in the asymptomatic patient, however, provides the physician with an opportunity to modify or correct underlying acquired causes of hyperuricemia


The incidence of gout in the USA is about 3/1000.

Gout is a group of pathological conditions associated with markedly elevated levels of urate in the blood (3-7 mg/dl normal).

Hyperuricemia is not always symptomatic, but, in certain individuals, something triggers the deposition of sodium urate crystals in joints and tissues.

 In addition to Gout and Hyperuricemia  the extreme pain accompanying acute attacks,  and repeated attacks lead to destruction of tissues and severe arthritic-like malformations.

The term gout should be restricted to hyperuricemia with the presence of these tophaceous deposits.

Urate in the blood could accumulate either through an overproduction and/or an underexcretion of uric acid.

In gouts caused by an overproduction of uric acid, the defects are in the control mechanisms governing the production of - not uric acid itself - but of the nucleotide precursors.

The only major control of urate production that we know so far is the availability of substrates (nucleotides, nucleosides or free bases).

One approach to the treatment of Gout and Hyperuricemia is the drug allopurinol, an isomer of hypoxanthine.

Allopurinol is a substrate for xanthine oxidase, but the product binds so tightly that the enzyme is now unable to oxidized its normal substrate. Uric acid production is diminished and xanthine and hypoxanthine levels in the blood rise. These are more soluble than urate and are less likely to deposit as crystals in the joints. Another approach is to stimulate the secretion of urate in the urine.

Summary

In summary, all, except ring-methylated, purines are deaminated (with the amino group contributing to the general ammonia pool) and the rings oxidized to uric acid for excretion. Since the purine ring is excreted intact, no energy benefit accrues to man from these carbons. Gout

Recent Articles

  1. Sambazon Acai original for gout

    Sep 04, 17 04:24 PM

    I have gout and I often drink Sambazon Acai original organic drink for about 3 days and my pain is gone. Better than any medication and pain killers. But

    Read More

  2. What is Gout

    Aug 26, 17 02:48 AM

    What is Gout - Gout, the oldest and most common form of Arthritis. The latest information on causes and symptoms of Gout, remedies and facts.

    Read More

  3. 1st time hopefully the last

    Aug 21, 17 03:58 AM

    I'm a first timer with gout and I wonder if moscato caused it. I tried it for the first time on my birthday and a few days later I had gout. Happy birthday!!

    Read More