Gout and Stress

Gout and stress


I don't know about you but sometimes I believe that during raised mental and emotional times that I have had a bout of Gout appear.

Generally only smaller attacks, but I don't think it is coincidence.

Stress generally is suppressed with a few extra drinks of alcohol and sometimes a few extra feeds of bad food to make one feel better.

My blood pressure would also rise, so would my anger or my sadness.

Now with a raised emotional state in any form also raises the Uric acid levels..The Number one enemy of Gout..



I have found out that in times of emotional strain we burn up our levels of Pantothenic acid which is a form of Vitamin B ( B5 ).

This acid is required in the excretion process of Uric acid, so a depleted Pantothenic Acid level leads to a potential Gout attack.


Uric acid crystals associated with Gout also activate the NALP3 Inflammasome. ( Cryopyrin ). Part of the Protein family which also includes NALP1, NALP2,and NALP 3.

The reason I mention these inflammasomes is that these protein families can sense stress.
These inflammasomes form and drive any hereditary autoinflammatorysyndromes such as Gout an Pseudogout.

MSU crystals have been identified after the release of uric acid dying cells which can then activate the NALP family.

Monosodium urate ( MSU)and calcium pyrophosphate dihydrate crystals (CPPD ) both enhance the engagement of NALP3 Inflammasone.

Sorry its confusing but there is not much out there that is nontechnical to show Gout and Stress are related.

Now there are a few schools of thought here with regards to "If Gout and Stress " are actually related.

One says this is not associated at all others seem to regards that stress is a major factor.

You have to be the judge of this because only you know how your body functions, but I believe you have to be more aware of how your body works with regards to Gout and you need to look deeply or keep a record of when your attacks occur. Because after all the way to maintain Gout is by learning what triggers it in the first place.

We are all different in what triggers a Gouty attack.

I believe that Stress has brought on my bouts from time to time, so when I am stressing out at work then I drink plenty of fluids and occasionally take a multi vitamin with Vitamin B5 in it.

I have added a section below for anyone that has or can relate to Gout and Stress, feel free to send an article in to me and I will add it to this page.








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What Other Visitors Have Said

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Gout and Stress

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